Aptamer-Targeted DNA Nanostructures for Therapeutic Delivery
نویسندگان
چکیده
منابع مشابه
Aptamer-Targeted DNA Nanostructures for Therapeutic Delivery
DNA-based nanostructures have been widely used in various applications due to their structural diversity, programmability, and uniform structures. Their intrinsic biocompatibility and biodegradability further motivates the investigation of DNA-based nanostructures as delivery vehicles. Incorporating AS1411 aptamers into DNA pyramids leads to enhanced intracellular uptake and selectively inhibit...
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Effective therapeutic vaccines often require activation of T cell-mediated immunity. Robust T cell activation, including CD8 T cell responses, can be achieved using antibodies or antibody fragments to direct antigens of interest to professional antigen presenting cells. This approach represents an important advance in enhancing vaccine efficacy. Nucleic acid aptamers present a promising alterna...
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ژورنال
عنوان ژورنال: Molecular Pharmaceutics
سال: 2014
ISSN: 1543-8384,1543-8392
DOI: 10.1021/mp500047b